The most potent cannabinoid is tetrahydrocannabiphorol, more commonly mentioned as THCP. THCP has seven carbon atoms in its alkyl side chain, making it the foremost potent cannabinoid that currently exists. For comparison, delta 9 THC has only five carbon atoms. THCP is believed to be up to 33 times more powerful than THC.
Not all cannabinoids are created equal — some are much, much stronger than others. we’ve created an inventory of the main cannabinoids found in cannabis plants to know better their effects. We’re basing this ranking on a mixture of private testing and research project exploring the binding capacity of every cannabinoid.
How to measure potent Cannabinoid:
For THC and its psychoactive analogs, potency depends on the amount of carbon atoms within the alkyl side chain of the molecule. A molecule with eight carbon atoms would fit perfectly in our CB1 and CB2 receptors, making it the foremost potent a cannabinoid could possibly be. However, no natural cannabinoid has this many carbon atoms within the alkyl side chain.
Molecules with fewer than three carbon atoms won’t bind with endocannabinoid receptors in the least , in order that they won’t provide a psychoactive experience. Those with three offer a light high, and every additional atom increases the potency.
Illustration of THCP Chemical Structure: THCP is at the highest of the spectrum of cannabinoid potency by an extended shot. Early research suggests it’s up to 33 times stronger than delta 9 THC, but after testing it ourselves, we’d place it somewhere within the 10X range.
There are other cannabinoids that are stronger, but they don’t occur in nature and have a tendency to return with tons of risks. THCP is found naturally in both hemp and marijuana in small concentrations.
Illustration of THC-O chemical structure: THC-O may be a THC analog that has an equivalent number of carbon atoms in its alkyl side chain. The key difference with this cannabinoid is that the acetate group that replaces the hydroxy group found in delta 9 THC with an acetate group.
This chickenfeed makes THC-O significantly more bioavailable than the other sort of THC. Its increased potency comes from a better uptake of the molecule into the bloodstream and brain. This Cannabinoid is later metabolized into delta 9 THC, which then exerts the psychoactive effects. THC-O is taken into account around 3 times as potent as delta 9 THC.
3. DELTA 9 THC
Illustration of Delta 9 THC chemical structure: Delta 9 THC is that the hottest and well-known potent cannabinoids.
It’s also the foremost prevalent psychoactive cannabinoid in marijuana plants, so other cannabinoids’ are compared thereto . this is often our baseline for assessing the relative potency of all other cannabinoids on this list.
Delta 9 THC has five carbon atoms in its alkyl side chain and a hydroxy group that permits the strong binding capability to CB1 CBD receptors.
Illustration of HHC chemical structure: Hexahydrocannabinol (HHC) may be a more stable sort of THC. It’s very similar in chemical structure to THC but is mentioned as “hydrogenated” because it contains additional hydrogen atoms that break the covalent bond (delta) found on other sorts of THC molecules.
The added hydrogen atoms produce a less snug fit into CB1 receptors, so HHC is about 80% as potent as delta 9 THC.
5. DELTA 8 THC
Illustration of Delta 8 THC Chemical Structure: Delta 8 THC is almost just like delta 9 THC in molecular structure. However, the difference between potent cannabinoids, delta 8 and delta 9 is that the covalent bond of the carbon chain in THC is within the eighth position.
Our Delta 8 THC is around 50-65% as potent as delta 9 THC. Most users report a clear-headed psychoactive experience and relaxation with a lower risk of unwanted side effects, like paranoia and anxiety.
6. DELTA 10 THC
Illustration of Delta 8 THC Chemical Structure: As the name suggests, delta 10 THC is additionally almost identical in structure to delta 9 THC. This cannabinoid has the covalent bond within the carbon chain shifted to the tenth position, the most difference of delta 10 and delta 9 THC.
Delta 10 THC is around 50% as potent as delta 9 THC. Most users report improved focus and a spotlight , also as a lift to energy and mood.
Illustration of THCv chemical structure: Tetrahydrocannabivarin (THCV) has just three carbon atoms within the alkyl side chain, but it’s otherwise just like delta 9 THC and other potent cannabinoids. With the minimum number of carbon atoms within the side chain to still produce a psychoactive effect, THCV is approximately 25% as potent as delta 9 THC.
Illustration of CBN chemical structure: Medical Cannabinoids (CBN) has five carbon atoms within the alkyl side chain, a bit like delta 9 THC. However, it’s two additional double bonds within the carbon ring and two fewer hydrogen atoms.
CBN is made as THC breaks down and thus maintains a number of its psychoactive properties. The differences in CBN’s molecular structure could be minor, but they create it far less likely to bind to CB1 receptors. CBN is approximately 10% as potent as delta 9 THC.
9. CBD & OTHERS (NON-PSYCHOACTIVE)
Illustration of potent cannabinoids Chemical Structure: The rest of the cannabinoids can all be listed within the same category as they’re entirely non-psychoactive. Cannabinoids like CBD, CBC, CBDV, CBCV, and THCC don’t directly activate the CB1 receptors and thus won’t make users feel high. Even very large doses of those cannabinoids won’t cause psychoactive properties. you’ll also check our recent article about CBD and its difference to delta 8.
However, many of them will cause some sort of body sensation. Users may feel a touch bit heavier or lighter and more relaxed overall.
10. CBG (ANTI-PSYCHOACTIVE)
Illustration of CBG chemical structure: If you compare CBN to CBG, the latter is during a class of its own because not only is it non-psychoactive — studies have found it actually negates a number of the psychoactive properties of other cannabinoids, like THC.
As such, this cannabinoid is usually utilized in combination with THC to scale back the psychoactive “load” of those products. this is often good for people that want to experience the health benefits of THC but don’t necessarily want to feel super stoned within the process.
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